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Best sinus medicines - August 2025

Last Updated - August 13, 2025

1
Best Choice
19% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mucinex
19% Off

Mucinex Sinus-Max Liquid Gels for Day and Night, 24 Count

Mucinex

$15.29

$18.98
(19% Off)

More Details
Main highlights
- TRUSTED COLD and COUGH BRAND: Cold and Cough brand doctors trust
- MAXIMUM STRENGTH MUCINEX SINUS-MAX NIGHT: Helps relieve pain, sinus pressure, nasal congestion, cough, and runny nose and sneezing
- MAXIMUM STRENGTH MUCINEX SINUS-MAX DAY: Helps relieve pain, sinus pressure, headache, nasal and chest congestion and thins and loosens mucus
- ACTIVE INGREDIENTS IN NIGHT: Contains Acetaminophen for pain relief, Dextromethorphan HBr for cough suppression, Doxylamine Succinate as an Antihistamine and Phenylephrine HCl for nasal decongestion
- ACTIVE INGREDIENTS IN DAY: Contains Acetaminophen for pain relief, Dextromethorphan HBr for cough suppression, Guaifenesin as an expectorant and Phenylephrine HCl for nasal decongestion
$15.29
$18.98 (19% Off)
2
16% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

GenCare
16% Off

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

GenCare

$14.99

$17.99
(16% Off)

More Details
Main highlights
- ULTIMATE SINUS RELIEF - Experience maximum strength nasal decongestion and sinus pressure relief from indoor or outdoor allergies or common cold symptoms. 10 mg of Phenylephrine HCl helps alleviate pressure in your nose, sinus, ears, and throat.
- NON DROWSY FORMULA - GenCare Nasal Decongestion can be taken any time of day including the morning or daytime. Many decongestant treatments are only suitable for nighttime use and are therefore limited for active adults and kids who need relief all day long.
- BULK SAVINGS BOTTLE - Stop worrying about constant refills with our value savings 300 tablet family size bottle. This is the perfect size for families or people who suffer from chronic congestion due to allergies or seasonal illness.
- BREATHE EASIER - Lowering sinus pressure and eliminating congestion can help you breathe better and deeper during the day or night. This over the counter decongestant can help with common symptoms like runny nose or blocked nasal passages.
- 100% SATISFACTION GUARANTEE - We know you and your family will love the ultimate convenience of our 300 count bulk savings bottle. That's why we back up each tamper proof bottle with our 100% Satisfaction Guarantee. Join thousands of nasal decongestion customers...Click Add-to-Cart Today
$14.99
$17.99 (16% Off)
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Sudafed

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

Sudafed

$10.99

More Details
Main highlights
- PHENYLEPHRINE & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant that provides non-drowsy relief, plus, 325 mg of acetaminophen, a pain and fever reducer
- NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus, helps relieve sinus pressure and sinus headaches
- HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time period
- FSA HSA APPROVED PRODUCT: Sinus congestion relief and pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible. Product eligibility may vary by plan
- DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
$10.99
4
Best Value
23% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol
23% Off

Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

Tylenol

$8.12

$10.67
(23% Off)

More Details
Main highlights
- The non-drowsy formula of this sinus decongestant medicine provides effective daytime symptom relief by promoting sinus drainage, decongesting sinus openings and passages, and thinning bronchial secretions to help make coughs more productive
- Pain reliever, fever reducer, decongestant and expectorant medicine temporarily relieves minor aches and pains as well as symptoms of chest congestion, nasal congestion, sinus headache and pressure
- From the #1 doctor recommended pain relief brand, these severe sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief
- Each caplet contains 325 milligrams of acetaminophen to reduce fever and pain; 5 milligrams of nasal decongestant phenylephrine HCl to help clear nasal passages; and 200 milligrams of the expectorant guaifenesin to help make coughs more productive
- 24-count of Tylenol Sinus Severe Daytime Medicine Caplets for non-drowsy relief of symptoms due to the common cold, flu, hay fever or other respiratory allergies such as mucus and sinus congestion
$8.12
$10.67 (23% Off)
5

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Vicks

Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

Vicks

$8.54

More Details
Main highlights
- This product is not formulated with an antihistimine allergy medicine and is not intended to treat runny nose, itchy & watery eyes, or sneezing
- The powerful, non-drowsy nasal decongestant medicine, expectorant, and pain reliever help to provide all in one relief for your sinus symptoms!
- HSA and FSA eligible, Check with your provider for more details
- Experience fast, powerful relief from nasal congestion, sinus pressure, sinus headache, sinus pain, chest congestion and mucus!
- Best suited to treat sinus symptoms caused by the common cold, hay fever, or other upper respiratory allergies because it thins and loosens mucus, reduces pressure in the sinuses, and relieves sinus pain!
$8.54

Best sinus medicines - August 2025

Mucinex Sinus-Max Liquid Gels for Day and Night, 24 Count

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

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Boiron SinusCalm Tablets for Sinus Pain Relief, Runny Nose, Congestion, Sinus Pressure, Headache - 60 Count

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Sudafed PE Head Congestion + Mucus Relief Tablets for Sinus Pressure, Congestion, & Headache, Non-Drowsy Decongestant with Acetaminophen, Guaifenesin & Phenylephrine HCI, 24 ct

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 10 Coated Tablets

Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct

Alka-Seltzer Plus Maximum Strength Power Max Sinus, Allergy and Cough Medicine for Adults and Children 12 Years and Older - Relieves Symptoms from Allergies, Colds or Hay Fever, 24 Count

Vicks Sinex SEVERE LiquiCaps, All-In-One Sinus Relief, Non-Drowsy, Nasal Decongestant, Maximum Strength Relief of Sinus Headache, Pain, Pressure, & Congestion, 24 LiquiCaps

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