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Best pain relievers - August 2025

Last Updated - August 6, 2025

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advil

Advil Pain Reliever and Fever Reducer, Ibuprofen 200mg for Pain Relief - 300 Count, Advil PM Pain Reliever and Nighttime Sleep Aid, Ibuprofen for Pain Relief and Diphenhydramine Citrate - 2 Count

Advil

$23.49

More Details
Main highlights
- One 300 count bottle of Advil Pain Reliever and Fever Reducer Coated Tablets and 2 count pack of Advil PM Pain Reliever and Nighttime Sleep Aid Caplets
- Ibuprofen PM provides headache relief, arthritis pain relief and joint pain relief, and this back pain medication helps relieve occasional sleeplessness related to minor aches and pains
- HSA and FSA eligible product
- Coated Advil tablets are easy to swallow pain relievers, providing relief that lasts for up to 6 hours
- Advil ibuprofen 200mg pain reliever is a back pain medicine, headache medicine, arthritis pain reliever and pain medicine, and new packaging will feature 20% less plastic to keep nearly 500,000 pounds of plastic out of landfills
- Advil PM Nighttime Pain Reliever caplets give you the restful sleep you need, helping you fall asleep and stay asleep so your body can heal as you rest
$23.49
2
20% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Aleve
20% Off

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

Aleve

$19.99

$24.99
(20% Off)

More Details
Main highlights
- Up to 12-Hours of Uninterrupted Pain Relief: Aleve Back & Muscle Pain Relief Tablets provide long-lasting back pain and muscle pain relief
- Targeted Pain Relief: Every tablet is made with 220 mg of naproxen sodium to help you take on muscle pain and provide back pain relief
- Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
- Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
- Comes in small, easy-to-swallow tablets; use as directed
$19.99
$24.99 (20% Off)
3
Best Value
24% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol
24% Off

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

Tylenol

$12.47

$16.59
(24% Off)

More Details
Main highlights
- With 500 mg of acetaminophen per gelcap, this extra strength oral pain reliever is fast-acting and can be used by adults and children who are 12 years and older
- Use as a fever reducer and to relieve minor aches and pains including headache, backache, toothache, menstrual and premenstrual cramps, minor pain of arthritis, joint and muscle pain, and pain caused by the common cold and flu
- Experience relief of minor aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction
- Each pain reliever gelcap features laser-drilled holes to quickly release pain medicine and contains 500 mg of acetaminophen for fast, effective extra strength pain relief that works at the speed of life, while being gentle on the stomach
- 100-count Tylenol Extra Strength Rapid Release Gels pain relief medicine with acetaminophen work fast to temporarily relieve minor aches and pains, headaches, and help reduce fever
$12.47
$16.59 (24% Off)
4
11% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advil
11% Off

Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 200 Coated Tablets

Advil

$15.97

$17.98
(11% Off)

More Details
Main highlights
- Take these ibuprofen tablets as directed, taking one tablet every 4 to 6 hours while symptoms persist, or two tablets if pain or fever does not respond to one tablet
- One bottle of 200 Advil Pain Reliever and Fever Reducer Coated Tablets, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief
- New packaging features 20 percent less plastic to keep nearly 5,000 pounds of plastic out of landfills
- Headache pain relief, period pain relief, back pain medication and fever medicine for adults and children 12 years and older
- Headache medicine, back pain medicine, joint pain medicine or minor arthritis pain reliever that also provides menstrual pain relief, as well as relief of muscle aches or aches and pains from the common cold
- HSA and FSA eligible product
- Coated Advil tablets are easy to swallow pain relievers, providing relief that lasts for up to 6 hours- the perfect addition to your college dorm room essentials
- Advil ibuprofen pain reliever and fever reducer for adults provides longer lasting relief than Tylenol Extra Strength, targets pain at the sight of inflammation
$15.97
$17.98 (11% Off)
5

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Advil

Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 100 Coated Tablets

Advil

$9.88

More Details
Main highlights
- Take these ibuprofen tablets as directed, taking one tablet every 4 to 6 hours while symptoms persist, or two tablets if pain or fever does not respond to one tablet
- One bottle of 100 Advil Pain Reliever and Fever Reducer Coated Tablets, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief
- Headache pain relief, period pain relief, back pain medication and fever medicine for adults and children 12 years and older
- Headache medicine, back pain medicine, joint pain medicine or minor arthritis pain reliever that also provides menstrual pain relief, as well as relief of muscle aches or aches and pains from the common cold
- HSA and FSA eligible product
- Coated Advil tablets are easy to swallow pain relievers, providing relief that lasts for up to 6 hours
- Advil ibuprofen pain reliever and fever reducer for adults provides longer lasting relief than Tylenol Extra Strength, targets pain at the sight of inflammation, and new packaging features 20 percent less plastic to keep nearly 5,000 pounds of plastic out of landfills
$9.88

Best pain relievers - August 2025

Advil Pain Reliever and Fever Reducer, Ibuprofen 200mg for Pain Relief - 300 Count, Advil PM Pain Reliever and Nighttime Sleep Aid, Ibuprofen for Pain Relief and Diphenhydramine Citrate - 2 Count

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 200 Coated Tablets

Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 100 Coated Tablets

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Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count (Packaging may vary)

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 100 Count (Packaging may vary)

Tylenol 8 Hour Acetaminophen 650 mg Extended Release Caplets, Fast Acting Bi-Layer Design, Quick & Long Lasting Pain Relief for Muscle, Joint, Back & Arthritis Aches, Fever Reducer, 100 Count

Motrin Dual Action with Tylenol, Ibuprofen & Acetaminophen Fast-Acting Dual Action Pain Reliever for Minor Aches & Pains, Ibuprofen (NSAID) 125 mg & Acetaminophen 250 mg, 120 ct

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